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Indiana vs. Michigan State prediction, odds, time: 2026 college basketball picks from proven model

March 1, 2026
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Two Big Ten blue bloods will meet on Sunday on CBS and Paramount+ when the Michigan St. Spartans visit the Indiana Hoosiers. No. 13 MSU (23-5, 13-4 Big Ten) has won three straight contests, most recently defeating Purdue 76-74 on Thursday. The Hoosiers (17-11, 8-9 Big Ten) have dropped three straight contests overall and are coming off a 72-68 Tuesday loss to Northwestern. MSU leads the all-time series 27-18.

Tipoff is at 3:45 p.m. ET from Assembly Hall in Bloomington, Ind. The Spartans prevailed, 81-60, when these teams met in Michigan on Jan. 13. The Spartans are 2.5-point favorites in the latest Indiana vs. Michigan State odds, while the over/under for total points scored is 144.5. The Spartans are at -161 on the money line. Before making any Michigan State vs. Indiana college basketball picks, check out the men’s college basketball predictions and betting advice from the SportsLine Projection Model.

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New users can also target the DraftKings promo code, which offers $200 in bonus bets if your $5+ bet wins:

The SportsLine Projection Model simulates every college basketball game 10,000 times and it enters Week 17 on a sizzling 11-1 run on its top-rated over/under college basketball picks dating back to last season, and is on a 20-11 run on top-rated CBB side picks. Anyone following its college basketball betting advice at sportsbooks and on betting apps could have seen strong returns.

Now, the model has simulated Michigan State vs. Indiana 10,000 times and just revealed its coveted men’s college basketball picks and betting predictions. You can head to SportsLine now to see the model’s picks. Here are several men’s college basketball odds and men’s college basketball betting lines for Indiana vs. Michigan State:

Michigan State vs. Indiana spread:    

Michigan State -2.5 at DraftKings

Michigan State vs. Indiana over/under:    

144.5 points

Michigan State vs. Indiana money line:    

Michigan State -161, Indiana +135

Michigan State vs. Indiana picks:    

See picks at SportsLine

Michigan State vs. Indiana streaming:

Paramount+ (sign up here)

New users can also target the latest Underdog promo code, good for $75 in fantasy bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.

Top Indiana vs. Michigan State predictions

SportsLine’s model has simulated Michigan State vs. Indiana 10,000 times and is going Over on the total (144.5 points). Totals in the mid 140s like this one have leaned over for the Spartans as the Over is 4-2 when the O/U is between 142 and 147 this season. MSU has also engaged in high-scoring games versus teams that struggle defensively as Michigan State has eclipsed the total in five of six road games versus teams allowing over 72 ppg, with IU giving up 72.1 points per contest.

The Over is 7-1, overall, over Michigan State’s last eight games, while Ohio State has seen the Over go 4-3 over its last seven matchups. Both squads are projected to have four double-digit scorers, with each team allowing multiple more points than what it gives up on average. The teams combine for 149 points, per the simulations, with the Over hitting in 63.1% of simulations.

How to make Michigan State vs. Indiana picks

The model also says one side of the spread hits almost 60% of the time. You can only see that pick at SportsLine.

So who wins Indiana vs. Michigan State, and which side of the spread hits in almost 60% of simulations? Visit SportsLine now to see which side of the Michigan State vs. Indiana spread to back, all from the advanced model that has simulated this game 10,000 times, and find out.



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